William and Catherine Gladstone were married in 1838. They had 8 Children as set out below:
William Henry Gladstone (1840–1891), MP.
Agnes Gladstone (1842–1931), later Mrs. Edward Wickham.
The Rev. Stephen Edward Gladstone (1844–1920).
Catherine Jessy Gladstone (1845–1850).
Mary Gladstone (1847–1927), later Mrs. Harry Drew.
Helen Gladstone (1849–1925), Vice-President of Newnham College, Cambridge
Henry Neville Gladstone (1852–1935), Lord Gladstone of Hawarden.
Herbert John Gladstone (1854–1930), MP and Viscount Gladstone.
It can be noted that the majority of the children went on to have long lives and successful careers however you can see that his second daughter Catherine Jessy Gladstone tragically, though not uncommonly at the time, only lived until the age of 4. It is said that she died of Meningitis.
William Henry Gladstone, Gladstone’s eldest son was born in Hawarden, Flintshire, Wales. He attended Eton College and read Greek and Latin at Christ Church, Oxford University. He was an MP for a total of 20 years, representing Chester for 3, Whitby for 12 and East Worcestershire for 5.
A singer and organist, he was well versed in musical history, especially the development of Anglican church music. One of the views he expressed was that choral church services were to be deplored because "the choirs often discourage the congregations from singing"! He wrote the anthems "Gracious and Righteous" and "Withdraw Not Thou" and also composed the hymn tunes Hammersmith, to which "Dear Lord and Father of Mankind" is sometimes set, and Ombersley, sometimes used for "Lord of All Being, Throned Afar". William also played for Scotland in the first unofficial England v Scotland Football International in 1870. When his mother's brother Sir Stephen Glynne died without heirs in 1874, William inherited the Glynne estates, including Hawarden Castle, where William Gladstone’s family had always lived.
He was appointed High Sheriff of Flintshire for 1888. He died in London on 4 July 1891; his son William Glynne Charles Gladstone inherited the Hawarden Estate. His funeral at Hawarden was extremely well attended, and the poor of the parish were said to have "unmistakeably felt that they had lost a most kind and generous benefactor".
in the Fields and christened there on 24 November 1842  She married Rev. Edward Charles Wickham, Headmaster of Wellington College, son of Rev. Edward and Christina Wickham, in 1873 at Chester, Cheshire  and they had two sons William and Edward and two daughters, Lucy and Mary.