Helen was the Gladstone’s youngest daughter and was born and christened on 21st September 1849 in Hawarden, Flintshire.
Her sister Mary encouraged her to study at Newnham College, Cambridge and when she had completed her course, she became assistant to the first principal Anne Clough. She later became Vice principal of Newnham in 1892. She and Octavia Hill helped to found the Women's University Settlement, now known as the Blackfriars settlement, and became its first warden. In the 1911 census she is at Hawarden.
Helen died at Sundial, Hawarden in 1925 aged 75 and was buried at Hawarden Churchyard.